Liming Pei
Associate Professor of Pathology and Laboratory Medicine at the University of Pennsylvania.
Metabolic dysregulation has long been associated with many human diseases including heart disease, diabetes and obesity. Research in recent years has also linked disordered metabolism to cancer, stem cell function, development and almost every aspect of biology. However, how metabolism is regulated at the molecular, genomic, cellular and organismal levels is still poorly understood. Why do mature neurons use glucose exclusively while the adult heart prefers fat as fuel source? Why do stem cells and many tumors prefer glycolysis while most differentiated cells exploit oxidative phosphorylation? Can we apply our knowledge of metabolism to the management of medical conditions – such as neurodegenerative disorders – not traditionally conceptualized as derangements of metabolism?
We strive to answer these questions utilizing a variety of experimental approaches from molecular and cell biology to genetics and genomics. The goal of our research is to understand metabolism and metabolic regulation in both normal physiology and disease states and apply this knowledge to human health and medicine.
Visit website: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8651729
See also: Perelman School of Medicine - Medical school of the University of Pennsylvania.
Details last updated 07-Jan-2021
Liming Pei News
Energy for muscles and brains controlled by a single protein
Salk Institute - 07-Apr-2015
Salk scientists discover a single protein that energizes both muscles and the brain. The study w...
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