Dr. Laura Donlin aims to deepen our understanding of autoimmune and musculoskeletal disorders by uncovering molecular patterns found within patient samples. The goal of this work is to create personalized treatment strategies based on patient-specific molecular signatures.

Working closely with HSS rheumatologists and surgeons, Dr. Donlin analyzes patient samples with cutting-edge molecular techniques such as next-generation sequencing. Combining these functional genomics analyses with drug response assays, Dr. Donlin looks to understand how the cellular and molecular profiles found within patient samples relate to treatment responses. Dr. Donlin and colleagues also use cell culture models to study how cells co-evolve during chronic inflammatory responses, with the intent of identifying novel therapeutic targets for autoimmune conditions such as rheumatoid arthritis.