A team led by Professor Jun-Ichi Hayashi from the University of Tsukuba in Japan, known as the white lion to his students given his white hair and powerful voice, challenges the current consensus surrounding the mitochondrial theory of aging, proposing epigenetic regulation, and not genetic mutation, may be responsible for the age-related effects seen in mitochondria. When Hayashi and colleagues tested their theory, they reversed the age defects in cell lines collected from 97-year-old Japanese participants. They then singled out two genes involved in glycine production which they believed are responsible for the mitochondria reversal. The findings thus suggest that a glycine supplementation could help curb aging or age-related diseases.