Dr Appleby is an accomplished medicines developer, having operated in all phases of therapeutic development from discovery to commercial launch. He joins Mogrify from the Cell and Gene Therapy Catapult, where he was Executive Director and Chief Scientific Officer and led the R&D group focused on ATMP manufacturing processes and analytical development for five years. Prior to this, Dr Appleby was CSO for Cell and Gene Therapy in GSK’s Rare Diseases Unit, where he led the team that developed StrimvelisTM, the multi-award-winning and first autologous pediatric CD34+ stem cell gene therapy to be approved for commercial use. He also led for 2 years the ARSA gene therapy, which was later out-licensed to Orchard Therapeutics and recently approved as LenmeldyTM.

Dr Appleby previously held the position of Director and Portfolio Manager at the GSK Centre of Excellence for External Drug Development, where he discovered, in-licensed, and developed new technologies and assets across a broad range of therapeutic areas. He graduated from the University of Leeds with an honors degree in Genetics and a PhD from the Department of Biochemistry and Molecular Biology.