The John Radcliffe Hospital (JR) is Oxfordshire's main accident and emergency site. The JR provides acute medical and surgical services including trauma, intensive care and cardiothoracic services. It is situated in Headington, about three miles east of Oxford city centre. It is the largest of the Trust's hospitals, covering around 66 acres, and includes:

• Children's Hospital
• Eye Hospital
• Heart Centre
• West Wing
• Women's Centre

The John Radcliffe site also houses many departments of Oxford University Medical School, is home to the George Pickering Education Centre and base for most medical students who are trained throughout the Trust.

The John Radcliffe Hospital is supported by Oxford Hospitals Charity.