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Jennifer A. Doudna

Professor of Biochemistry, Biophysics and Structural Biology at UC Berkeley.

Research Expertise and Interest

RNA machines, hepatitis C virus, RNA interference, ribosomes, x-ray crystallography, cryo-electron microscopy, CRISPR-Cas9 genome editing

Research Description

RNA forms a variety of complex globular structures, some of which function like enzymes or form functional complexes with proteins. Our research into RNA biology led to the discovery of CRISPR-Cas9 as a tool for making targeted changes to the genome. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activation. Current research in the Doudna lab focuses on discovering and determining the mechanisms of novel CRISPR-Cas and associated proteins; developing genome editing tools for use in vitro, in plants, and in mammals; and developing anti-CRISPR agents.

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See also: Academia University of California, Berkeley - Public land-grant research university

Jennifer A. Doudna News

COVID-19 advanced testing lab created by UC Berkeley scientists

University of California, Berkeley - 30-Mar-2020

In response to mass testing needs, they employ robotics and automation for accuracy and speed


CRISPR Toolkit Expands With Trio of New Tricks

Singularity Hub - 27-Feb-2018

New CRISPR technologies are CAMERA, DETECTR, and SHERLOCK. CAMERA reads out for the cell’s histo...