Jennifer A. Doudna
Professor of Biochemistry, Biophysics and Structural Biology at UC Berkeley.
Research Expertise and Interest
RNA machines, hepatitis C virus, RNA interference, ribosomes, x-ray crystallography, cryo-electron microscopy, CRISPR-Cas9 genome editing
Research Description
RNA forms a variety of complex globular structures, some of which function like enzymes or form functional complexes with proteins. Our research into RNA biology led to the discovery of CRISPR-Cas9 as a tool for making targeted changes to the genome. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activation. Current research in the Doudna lab focuses on discovering and determining the mechanisms of novel CRISPR-Cas and associated proteins; developing genome editing tools for use in vitro, in plants, and in mammals; and developing anti-CRISPR agents.
Visit website: https://chemistry.berkeley.edu/faculty/chem/doudna
See also: University of California, Berkeley - Public land-grant research university
Details last updated 20-Mar-2020
Jennifer A. Doudna News
COVID-19 advanced testing lab created by UC Berkeley scientists
University of California, Berkeley - 30-Mar-2020
In response to mass testing needs, they employ robotics and automation for accuracy and speed
Read more...CRISPR Toolkit Expands With Trio of New Tricks
Singularity Hub - 27-Feb-2018
New CRISPR technologies are CAMERA, DETECTR, and SHERLOCK. CAMERA reads out for the cell’s histo...
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