The Hannon Laboratory relocated to the CRUK Cambridge Institute from Cold Spring Harbor Laboratories in late 2014. Our laboratory works to understand breast cancer from its earliest stages through to lethal metastatic disease.

The strong focus of the Hannon laboratory on small RNA biology, and in particular the discovery of the protein components of the miRNA pathway, fuelled the development of artificial short-hairpin RNAs (shRNAs) as a tool to robustly knock-down gene expression in vivo.