Dr. Gordon Guyatt is a Distinguished Professor in the Department of Clinical Epidemiology and Biostatistics, McMaster University and one of the founders of Evidence-Based Medicine. He has played a key role in over 30 major clinical studies (including both large-scale observational and randomized trials) and has extensive expertise in study methodology.  As co-founder and co-chair of the GRADE working group he has been intimately involved in the development and evolution of the GRADE approach.