This episode explores how the gut microbiome influences ageing and longevity. Researchers have found that changes in gut bacteria are not just a consequence of ageing but may actively drive the process. Through fecal transplant experiments in various species, scientists are uncovering the link between gut health and lifespan.

Key Points:

This episode highlights the growing evidence that the gut microbiome plays a causal role in ageing. By understanding and modifying gut bacteria, scientists may unlock new ways to extend healthspan and longevity.

• Microbiome & Lifespan in Model Organisms: Studies in worms (C. elegans) and fruit flies show that gut bacteria influence longevity. In flies, age-related microbiome changes predict lifespan, with harmful bacteria from older flies accelerating death.
• Fecal Transplants in Fish & Mice: Middle-aged killifish transplanted with gut bacteria from younger fish lived longer and remained more active. Microbe-free mice, which lack gut bacteria, live up to 50% longer, suggesting that gut microbes contribute to age-related inflammation.
• The Role of “Bad Bugs” in Ageing: Transplanting gut bacteria from older animals into young ones causes gut leakiness, inflammation, and reduced lifespan. However, young animals may resist these effects due to their stronger immune systems.
• Potential for Human Longevity: Fecal transplants from centenarians to mice showed anti-ageing benefits, including brain health improvements. These findings suggest a future where gut microbiome modulation could be a strategy for promoting healthy ageing.