In this candid solo episode, longevity researcher Matt Kaeberlein breaks down his personal healthspan strategy, explaining what he actively does to support long-term health—and, just as importantly, what he deliberately avoids. The discussion cuts through hype around supplements and emphasizes evidence, trade-offs, and realism.

Key Points:

This episode offers a grounded, no-hype look at personal longevity practice from a leading aging researcher. Matt argues that lifestyle interventions dwarf the impact of most supplements. The takeaway: focus on fundamentals, be honest about evidence, and don’t confuse optimization with excess.

• Healthspan over lifespan: Matt prioritizes staying healthy, functional, and disease-free for as long as possible, rather than chasing maximal lifespan at any cost.
• Lifestyle first, always: Exercise (especially strength training), sleep, stress management, and diet deliver far larger benefits than any pill, and form the foundation of his approach.
• Skepticism about supplements: Many popular longevity supplements lack strong human evidence; Matt avoids most due to weak data, potential risks, or negligible benefits.
• Risk–benefit realism: Even promising interventions can have downsides; Matt emphasizes understanding trade-offs instead of assuming “more is better.”
• Evidence-based experimentation: Personal choices are guided by animal data, human trials where available, and biological plausibility—not marketing or anecdotes.
• Why he skips ‘longevity stacks’: Combining multiple unproven supplements may increase cost and risk without additive benefit, especially when basic lifestyle factors aren’t optimized.