In this episode of Optispan, Dr. Greg Fahy explores his pioneering research on thymus regeneration and immune system rejuvenation. He delves into the TRIM protocol, highlighting the roles of growth hormone, DHEA, and metformin in reversing age-related immune decline. The discussion covers thymic involution’s impact on longevity, potential improvements in vaccine response, and broader health benefits. 

Key Points:

This episode sheds light on the critical role of thymus regeneration in ageing and offers a promising approach to enhancing immune health and longevity. The discussion delves into immune function, vaccine efficacy, and the wider impact of thymic involution on longevity and overall well-being.

• The TRIM Protocol & Thymus Regeneration: Dr. Fahy’s TRIM protocol uses growth hormone, DHEA, and metformin to regenerate the thymus, an organ essential for immune function. Research suggests that restoring thymic function could slow or even reverse aspects of immune ageing.
• Why Thymic Involution Matters: The thymus shrinks and accumulates fat with age, leading to weakened immunity, higher cancer risks, and reduced vaccine effectiveness. Removing the thymus in adults has been linked to increased mortality, cognitive decline, and disease recurrence.
• Growth Hormone, DHEA & Metformin: A Synergistic Approach: Growth hormone is critical for thymus regeneration but can cause insulin resistance. DHEA and metformin help counteract these metabolic side effects, making the treatment safer and more effective.
• Impact on Immune Function & Disease Prevention: The protocol has been shown to increase naïve T-cell production and improve immune surveillance against cancer and infections. Regenerating the thymus may also reduce age-related inflammation, which contributes to chronic diseases like heart disease and Alzheimer’s.
• Exercise Performance & Physiological Rejuvenation: Participants in Dr. Fahy’s trials showed significant improvements in muscle strength, VO₂ max, and metabolic health. Changes in biomarkers suggest a reversal of certain ageing-related declines.
• Future Research & Longevity Implications: Ongoing studies aim to refine the protocol, reduce treatment costs, and explore additional longevity benefits. Dr. Fahy’s work challenges traditional views on ageing, highlighting the potential to restore immune function and improve healthspan.