Our research interest is focused on understanding the role of central nervous system in the development and intervention of metabolic syndrome, aging and related diseases. First, we are studying the interactions between various signaling cascades and neuronal regulatory network that underlie the development of obesity- and aging-associated neural dysfunctions and subsequent whole-body pathophysiology. Second, we are identifying intrinsic molecular and cellular pathways which can counteract obesity- and aging-related neural dysfunctions. Finally, we are aiming to develop novel and effective strategies of molecular and cell therapies to break the pathogenic connections, leading to the prevention and treatment of metabolic and aging-related diseases.