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Carmela Abraham

Professor at Boston University School of Medicine.

Our laboratory studies the molecular mechanisms leading to normal brain aging and the pathological processes that culminate in Alzheimer’s disease. We utilize the rhesus monkey as a model for understanding changes that occur during non-pathological aging. With microarray analysis we identified genes that play crucial roles in brain dysfunction leading to cognitive decline. An example is Klotho, a cytoprotective, anti-aging protein. We found that Klotho expression is considerably decreased in the aged brains of monkeys, rats, and mice. We are now working to comprehensively characterize the role of Klotho in normal aging and disease. Our projects are to identify Klotho receptors in the brain and define the signaling pathways by which Klotho exerts its protective effects.

Visit website: https://www.bumc.bu.edu/biochemistry/profiles/carmela-abraham/

 carmela-abraham-3801661

See also: Academia Boston University - Private research university in Boston, Massachusetts

Details last updated 07-Dec-2019

Carmela Abraham News

Turbocharging the brain with Klotho

New York Times - 02-Apr-2019

Smart drugs will increase social disparity unless available to all

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Klotho hormone shows promise as a cognitive enhancer

Scientific American - 08-Aug-2017

Klotho injections improved memory and motor skills of mice

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