Carmela Abraham
Professor at Boston University School of Medicine.
Our laboratory studies the molecular mechanisms leading to normal brain aging and the pathological processes that culminate in Alzheimer’s disease. We utilize the rhesus monkey as a model for understanding changes that occur during non-pathological aging. With microarray analysis we identified genes that play crucial roles in brain dysfunction leading to cognitive decline. An example is Klotho, a cytoprotective, anti-aging protein. We found that Klotho expression is considerably decreased in the aged brains of monkeys, rats, and mice. We are now working to comprehensively characterize the role of Klotho in normal aging and disease. Our projects are to identify Klotho receptors in the brain and define the signaling pathways by which Klotho exerts its protective effects.
Visit website: https://www.bumc.bu.edu/biochemistry/profiles/carmela-abraham/
See also: Boston University - Private research university in Boston, Massachusetts
Details last updated 07-Dec-2019
Carmela Abraham News
Turbocharging the brain with Klotho
New York Times - 02-Apr-2019
Smart drugs will increase social disparity unless available to all
Read more...Klotho hormone shows promise as a cognitive enhancer
Scientific American - 08-Aug-2017
Klotho injections improved memory and motor skills of mice
Read more...