Dr. Alice Soragni’s lab focuses on two major and overlapping areas of research. First, they investigate how protein aggregation affects cancer development and progression, with a special focus on p53 aggregation. They exploit protein aggregation as a therapeutic target by designing peptides that interfere with the process.

Second, and in parallel, the lab focuses on developing clinically-relevant organoid models for cancer biology, as well as drug discovery and development applications. In particular, they establish tumor organoids from surgical specimens (patient-derived tumor organoids) and perform high-throughput drug screenings to individualize cancer therapy to each patient.