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Two types of type 1 diabetes in children: Endotype 1 and Endotype 2

This new understanding of the disease process could even lead to a cure in the future

16-Mar-2020

Key points from article :

T1 diabetics under 7 years don’t process insulin properly and cells that make it are quickly destroyed.

Those diagnosed at age 13 or above often continue to produce normal insulin.

It’s Endotype 1 if diagnosed before 7 years and Endotype 2 if diagnosed at 13 years or after.

Children diagnosed between the ages of 7 and 12 could fall into either the T1DE 1 or T1DE 2 group.

Could lead to new treatments if they can reactivate dormant insulin-producing cells in T1DE 2 group.

Studied 130 samples from Exeter pancreatic biobank.

Research by University of Exeter, published in Diabetologia.

Mentioned in this article:

Click on resource name for more details.

Diabetes UK

Leading charity for people living with diabetes in the UK.

Diabetologia

The journal provides information in the field of diabetes

Elizabeth Robertson

Director of Research at Diabetes UK

Juvenile Diabetes Research Foundation

A charity registered in England, Wales and Scotland to fight type 1 diabetes

Karen Addington

Chief Executive Officer at Juvenile Diabetes Research Foundation, UK

Noel Morgan

Professor of Endocrine Pharmacology at University of Exeter Medical School

Sarah J Richardson

Associate Professor in Cellular Biomedicine, University of Exeter Medical School

University of Exeter

UK university and member of the Russell Group of leading research-intensive UK universities

Topics mentioned on this page:
Diabetes