Key points from article :
New method to improve the efficiency of NMN and metformin in the liver by using a novel nanoparticle delivery method.
Metformin and NMN have the potential to be improved upon by more efficient and targeted delivery.
Researchers developed Ag2S quantum dots (QDs) to serve as a drug delivery vehicle.
QDs are only 7 nanometers in size, accumulate in the liver, after which they are rapidly cleared from the body.
QD-metformin and QD-NMN were absorbed by the small intestine dramatically faster, and accumulated in the liver in greater amounts.
QD-metformin was able to achieve the same effects as metformin alone with 100-fold lower dosing.
QD-NMN dosed at 1000-fold lower concentrations performed similarly to NMN only.
Conjugated drugs were utilizing endocytosis.
Improved outcomes were seen in older mice treated with QD-NMN.
Negligible cellular toxicity, inflammation or tissue damage for at least 100 days of daily intake.
Research by University of Sydney published in the journal ACS Nano.