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DNA nanorobot can target breast cancer cells for destruction


Key points from article :

20% of breast cancers make high levels of a human epidermal growth factor receptor 2 (HER2) protein.

Developed DNA nanorobot recognizes HER2 on breast cancer cells, targets them for destruction.

Sequence of DNA called an aptamer, binds HER2, targets it for destruction, but isn't stable in serum.

Team designed DNA nanostructure with an attached HER2 aptamer.

Nanorobots persisted in the bloodstream more than twice as long as the free aptamer.

Nanorobot being a much easier and less expensive way for treatment still needs improvement for further using.

Results published in the ACS journal Nano Letters.

Lowering the levels of HER2 slows cancer cell proliferation and triggers cell death

Mentioned in this article:

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Mayo Clinic

Non-profit American academic medical center focused on health care, education, and research

Nano Letters

Journal about nanoscience and nanotechnology.

Yunfeng Lin

Professor of State Key Laboratory of Oral Diseases, Sichuan University