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CRISPR gene-editing technology boosts cancer-fighting immune cells

Personalized T-cell therapy for untreatable cancers - further studies needed to test the dose and effectiveness

11-Nov-2022

Key points from article :

People with untreatable cancers have had their immune system redesigned to attack their own tumours.

In an experimental study on 16 patients, treatment was developed for targeting specific weak spots.

To boost levels of cancer-spotting T-cells, and it is tailored to each patient as each tumour is unique.

Researchers scoured patient's blood for T-cells that already had receptors which could sniff out their cancer.

Harvested other T-cells that could not find the cancer and redesigned them using gene-editing technology Crispr.

Modified cancer-searching T-cells were then put back into the patient.

Disease continued to get worse in 11 patients, but stabilised in the other five.

It is too early to fully assess the therapy's effectiveness and it is expensive and time-consuming.

"This is a leap forward in developing a personalised treatment for cancer," said Antoni Ribas, co-researcher.

It was a "powerful early demonstration of what might be possible with newer techniques", - Waseem Qasim,

Study published in the journal Nature.

Mentioned in this article:

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Antoni Ribas

Professor of medicine, surgery, and molecular and medical pharmacology at UCLA

Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Waseem Qasim

Professor of Cell and Gene therapy, Consultant Immunologist, Great Ormond Street hospital

Topics mentioned on this page:
Cancer, Precision Medicine
CRISPR gene-editing technology boosts cancer-fighting immune cells