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Carbon nanotubes deliver drugs directly to targeted site

05-May-2021

Key points from article :

Getting drugs into disease-ridden cells has remained a major challenge for modern pharmacology and medicine.

Carbon nanotubes enable direct drug delivery from liposomes into the cell.

A dimer of small-diameter carbon nanotube porins (CNTPs) functions as a potent promoter of membrane fusion.

Enhancing liposomal stability on the way to target and easing payload release into the cytosol of target cell.

When loaded with a chemotherapeutic agent (doxorubicin), these carriers delivered the drug to cancer cells, killing a majority of them.

"..provide the basis for constructing the long-desired versatile carrier for direct and highly efficient delivery of drugs and vaccines across the plasma membrane," - Alex Noy, lead researcher at LLNL.

"This strategy could bypass the endocytotic pathway entirely," - Gerhard Hummer, Biophysicist at Max Planck Institute.

Research by LLNL, University of California Merced, and Max Planck Institute of Biophysics published in PNAS.

Breakthrough strategy involving fusion of drug carrier membrane with the cell

Mentioned in this article:

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Academic

Research Scientist at Lawrence Livermore National Laboratory, Associate Adjunct Professor at UC Merced

Academic

Biophysicist, Director and Scientific Member at the Max Planck Institute

Institute

Federal research facility in Livermore, California.

Academia

Research organization based in Frankfurt, Germany

Academia

Public research university in Merced, California.