Key points from article :
Cold Spring Harbor Lab's research, led by Prof. Vakoc, targets turning cells of rhabdomyosarcoma (RMS), a type of cancer, into healthy muscle cells.
The research explores a treatment approach called differentiation therapy, where cancer cells are converted into normal tissue cells.
Genome editing identified RMS's genes like NF-Y that, when altered, turn RMS into normal muscle cells.
Impaired NF-Y causes RMS cells to lose the cancer traits and emphasise contraction.
This research represents a crucial step towards making differentiation therapy more accessible and effective in cancer treatment.
The discovery holds promise for revolutionising cancer therapy and improving the outlook for patients.
