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Bioengineered immune cells craft their own weapon against cancer


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Scientists at École Polytechnique Fédérale de Lausanne created supercharged immune cells (CAR T cells) for cancer treatment.

They engineered these cells to make their own medicine, a molecule called interleukin-10 (IL-10), to keep fighting even in the harsh environment around tumors.

This new immunotherapy completely eliminated cancer in mice, including melanoma, colon, breast, and pancreatic cancers.

It even prevented new tumors from forming when cancer cells were reintroduced.

Early human trials show promising results. All 11 patients achieved complete remission so far, with the potential for faster and cheaper treatment compared to existing options.

It has the potential to improve the effectiveness and accessibility of this treatment for many cancer patients.

The study was published in Nature Biotechnology, highlighting the significance and potential of this new immunotherapy technique.

CAR T cells are modified to produce interleukin-10, a molecule defeating various cancers

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Nature Biotechnology

Journal providing information from all areas of biotechnology.

Swiss Federal Institute of Technology Lausanne (EPFL)

University that specializes in natural sciences and engineering.

Bioengineered immune cells craft their own weapon against cancer