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A genetic mutation that happened 3 million years ago causes heart attacks

It may reduce atherosclerosis, but what about other chronic diseases?

22-Jul-2019

Key points from article :

2 - 3 million years ago a gene was inactivated in our ancestors due to genetic mutations.

Active form of this gene in chimpanzees protects them from heart attacks.

The inactivated gene named CMAH was responsible for making sialic acid molecule Neu5Gc.

Genetically modified mice that lacked Neu5Gc were twice at risk of atherosclerosis.

Feeding red meat rich in Neu5Gc to these mice further increased their risk of atherosclerosis.

Plans to develop an antidote to fight ill effects of eating red meat.

Study by University of California San Diego School of Medicine published in PNAS.

Mentioned in this article:

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Ajit Varki

Professor of Medicine and Cellular and Molecular Medicine.

Proceedings of the National Academy of Sciences (PNAS)

Multidisciplinary scientific journal, official journal of the National Academy of Sciences

UC San Diego School of Medicine

School for medical and scientific training.

Topics mentioned on this page:
Heart Disease