In this episode, Dr. Rhonda Patrick explores compelling new evidence linking vitamin D supplementation with a significantly reduced risk of dementia. The discussion blends cutting-edge research with practical advice on how to maintain optimal vitamin D levels for brain health.

Key Points:

This episode explores how something as simple as a daily vitamin D supplement could have profound effects on brain health and dementia risk. Vitamin D functions more like a potent steroid hormone, influencing nearly 5% of the human genome, including genes critical for brain function, memory, and inflammation control.

• Breakthrough Study Links Vitamin D to Lower Dementia Risk: A large-scale study of over 12,000 adults showed that taking vitamin D supplements was associated with a 40% reduction in dementia risk over 10 years.
• Genes, Cognitive Health & Supplement Impact: The protective effect was seen across populations, including those with mild cognitive impairment and carriers of the APOE4 gene, a major genetic risk factor for Alzheimer’s. Those with normal cognition at baseline benefited the most.
• Widespread Deficiency and Its Causes: Up to 70% of Americans are deficient or insufficient in vitamin D, largely due to low sun exposure, skin pigmentation, aging, and higher body fat—factors that impair natural vitamin D synthesis.
•  Small Daily Habit, Big Brain Benefits: A daily supplement of 2,000–4,000 IU can help maintain optimal vitamin D levels (30–60 ng/mL), supporting memory, reducing brain inflammation, and potentially slowing age-related cognitive decline.