Kaeberlein, who led the Kaeberlein lab at the University of Washington from 2006 to 2023, gathered several former lab members—including professors, start-up founders, and prospective PhD students—for a discussion on longevity interventions like metformin, acarbose, and sauna use. They shared insights on recent positive findings, unpublished data, and ongoing research from their labs, while also exploring nuances in recent studies, including results from the Interventions Testing Program discussed in a previous podcast episode.

Key Points:

This podcast episode features a reunion of Matt Kaeberlein and his former lab members, where they discuss their latest research on ageing and longevity. The group shares insights on various interventions, such as metformin, acarbose, and sauna use, debates emerging therapies, and explores unconventional methods for promoting healthy ageing.

• Reunion and Research Updates: Matt Kaeberlein and his former lab members gathered at the American Aging Association meeting to discuss their current research in ageing and longevity science.
• Diverse Research Interests: The team members are now working on a variety of topics, including mitochondrial dysfunction, microbiome, frailty, sex differences in ageing, and women's reproductive health.
• Discussion on Longevity Interventions: They explored various longevity interventions such as metformin, acarbose, and sauna use, sharing insights from recent studies and their own research findings.
• Debate on Emerging Therapies: The group debated the benefits and challenges of newer therapies like methylene blue, dasatinib plus quercetin, hyperbaric oxygen therapy, and branched-chain amino acid restriction, highlighting the need for further research.
• Importance of Translational Research: There was a strong emphasis on the need for real-world data and translational research to validate these interventions' effectiveness in human populations.
• Unconventional Longevity Methods: The episode also covered less conventional methods for promoting longevity, such as intermittent fasting, caloric restriction, and the concept of hormesis through practices like sauna and cold plunges.