In this episode of the NutritionFacts.org podcast, Dr. Michael Greger unpacks the science behind AMPK, the "master energy sensor" of the body. This enzyme not only governs fat metabolism but also plays a crucial role in ageing and mitochondrial health, making it a key target in longevity research.

Key Points:

This episode explores how the enzyme AMPK boosts fat burning, supports mitochondrial health, and slows ageing. With natural and pharmaceutical ways to activate AMPK, it offers a promising path for longevity and metabolic improvements.

• AMPK and Energy Balance: Acting as a universal fuel gauge, AMPK flips the body from fat storage to fat burning when energy is low, supporting weight loss and cellular efficiency.
• Longevity and Ageing: AMPK enhances autophagy and mitochondrial function, processes vital for cleaning up cellular damage, mitigating ageing, and extending lifespan across species.
• Natural Boosts to AMPK: Exercise, especially endurance activities, dramatically activates AMPK, leading to improved energy metabolism and increased cellular resilience.
• Metformin and AMPK: The popular diabetes drug metformin mimics AMPK’s effects, potentially offering the benefits of fasting and exercise for ageing and metabolic health.