His research interests are focused around understanding the inherited basis of common cardiovascular diseases, especially coronary artery disease and hypertension. He is a Principal Investigator on several national and international genetic projects on these diseases including the British Heart Foundation Family Heart Study (BHF-FHS), the British Genetics of Hypertension (BRIGHT) Study, the Genetic Regulation of Ambulatory Blood Pressure in the Community (GRAPHIC) Study, the Wellcome Trust Case Control Consortium (WTCCC), CARDIoGRAM  and ENGAGE. Recent work has focused on using genome-wide association approaches. A complementary area of research is investigating the role of biological ageing in cardiovascular diseases. He holds a British Heart Foundation Chair of Cardiology and is also a National Institute for Health Research Senior Investigator.