A major focus of Koronyo-Hamaoui’s research is investigating the role of innate immune cells – especially peripheral monocytes and macrophages – in CNS repair and regeneration, and the development of immunomodulation-based treatments for Alzheimer’s disease (AD). In addition, she is exploring the pathological changes in the retina specific to AD for the prospect of early screening and tracking response to therapy. She is a pioneer in identifying the pathological hallmark of AD, Aβ plaques, in the retina of AD patients, including early-stage cases. Her team further developed a breakthrough noninvasive approach for detection of retinal Aβ deposits in living patients using high-resolution optical retinal imaging. Currently, her lab is probing neuroinflammation, tauopathy and vascular biomarkers in the retina of MCI and AD patients while establishing their relationship with disease in the brain.