Parkinson’s patients remarkable recoveries in drug trial
Independent - 19-Oct-2015Nilotinib has been used to treat patients with a certain type of leukaemia. Works by boosting th...
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Associate Professor of Neurology at Georgetown University Medical Center.
I am an Associate Professor of Neurology at Georgetown University Medical Center (GUMC). My expertise is in geriatric neurology with a special focus on movement and memory disorders. I received a Bachelor of Medicine, Bachelor of Surgery (MBBS), and Doctor of Philosophy (Ph.D) in Biomedical Sciences from the University of Sydney Australia. I am the director of GUMC Translational Neurotherapeutics Program and the Laboratory for Dementia and Parkinsonism (https://sites.google.com/a/georgetown.edu/moussa-lab/home). I serve as the Principal Investigator of the GUMC Lewy Body Disease Association (LBDA) Research Center of Excellence. I am a neuroscientist focused on the role of tyrosine kinases and de-ubiquitinases on protein ubiquitination and proteasome-autophagy clearance in neurodegenerative diseases. In collaboration with the Medicinal Chemistry Core Center at Georgetown University I generated several tyrosine kinase inhibitors (TKIs) that are being investigated as potential therapies for neurodegenerative diseases. I have discovered the potential use of cancer drugs nilotinib (Abl/DDR inhibitor) and bosutinib (Src/Abl Inhibitor) as a treatment for neurodegenerative diseases. I identified a potential novel drug target known as discoidin domain receptor (DDR)-1 that can induce autophagic clearance of misfolded proteins in preclinical and clinical settings.
Visit website: https://neurology.georgetown.edu/moussa/
See also: Georgetown University Medical Centre - Academic health and science center.
Details last updated 17-Jul-2020
Nilotinib has been used to treat patients with a certain type of leukaemia. Works by boosting th...