Senescence fuels heart disease: new ways to tackle ageing cells

Live Forever Club - 09-Nov-2024

Targeting senescent cells may prevent disease progression and show promise

Cellular senescence surprisingly supports meniscus repair in rats

Live Forever Club - 05-Nov-2024

Early removal of these cells slows recovery, highlighting their short-term benefits

Air pollution, particularly PM2.5, accelerates ageing and increases disease risk

Live Forever Club - 26-Sep-2024

You can protect yourself by wearing masks, using air purifiers, and avoiding polluted areas

Five Alarm Bio's small molecules fight ageing and improve longevity

Live Forever Club - 11-Sep-2024

FAB1 compound reduces ageing markers in cells while FAB15 accelerates wound healing

Senolytic drugs show promise for bone health in postmenopausal women

Mayo Clinic - 02-Jul-2024

But, senolytic therapy may not be a universal solution for age-related bone loss

Senescent cells, traditionally linked to ageing, surprisingly play vital roles in body

Science - 20-Jun-2024

This could have implications for developing new therapies

New drug delivery system targets cells in the bodies that are linked to ageing

Live Forever Club - 13-Jun-2024

This offers a safer, more effective treatment for age-related diseases

Keto diet accelerated organ aging in mice due to increased senescent cells

New Scientist - 17-May-2024

Switching the mice back to a standard diet reduced the damage

Clearing senescent cells improves immediate immunity to influenza in aged mice

Live Forever Club - 14-May-2024

It may hinder the development of long-lasting protection against future infections

Rubedo secures $40 million to advance its age-targeting treatments into clinical trials

Longevity Technology - 22-Apr-2024

Potentially leading to breakthroughs in managing chronic diseases

Urine-derived stem cells release anti-ageing molecules that changed mice ageing

Live Forever Club - 31-Mar-2024

The discovery reveals the body's potential for self-rejuvenation

SENISCA secures 3.7 million euros to fight aging with RNA-based therapies

Longevity Technology - 18-Mar-2024

Developing senotherapeutics to target cellular senescence and treat age-related diseases

Senolytic drugs offered mixed clues about their potential impact on ageing

Fight Aging! - 04-Mar-2024

While modifying immune cell populations, the drugs also increased ageing biomarkers

Researchers explore the potential of sound waves for anti-ageing

Lifespan.io (LEAF) - 09-Feb-2024

Originally used to fight cancer, sound waves surprisingly revive old cells

Mice who sipped green tea all their lives lived longer and stayed healthier

Live Forever Club - 04-Feb-2024

Green tea improved gut health and boosted the immune system in mice

T cells engineered to target and remove damaged cells in mice

Medical News Today - 31-Jan-2024

The treated mice showed better health, including improved metabolism and activity

Having too much iron in your body can damage organs like lungs and kidneys

Live Forever Club - 28-Jan-2024

This could impact how much iron we get from food or supplements

New immune cells can recognise and eliminate a specific protein on ageing cells

Live Forever Club - 25-Jan-2024

In mice, this therapy was shown to reduce the number of senescent cells

A new method called FAST studies cellular ageing in cultured cells

Live Forever Club - 18-Jan-2024

FAST is precise and works with different cell types and microscopes

Fisetin in berries and apples could shield your heart in later years

Live Forever Club - 19-Dec-2023

Supplementation reduced the buildup of senescent cells in the arteries of aged mice

Ageing eyes face a double whammy of senescent cells and weakened defenses

Live Forever Club - 19-Dec-2023

Senolytic intervention helps to repair the protective barrier of the eyes

Your daily choices, whether at the gym or in your meals, can redefine your age

Live Forever Club - 15-Dec-2023

Cellular senescence can be significantly mitigated by a holistic lifestyle

Senescent cell weakness exploited by new anti-aging therapy

Singularity Hub - 07-Nov-2023

FDA-approved drug kills zombie cells and improves organ function in elderly mice

Senolytics may rejuvenate heart cells and prevent age-related heart disease

Live Forever Club - 02-Nov-2023

Drugs have the potential to revolutionise the way we treat age-related diseases

New peptide-based technology selectively erases ageing cells

Ulsan National Institute of Science and Technology (UNIST) - 14-Sep-2023

Mitochondria targeting could lead to new treatments for age-related diseases

Phase I trial shows early promise in clearing senescent cells in Alzheimer's

Wake Forest Baptist Health - 07-Sep-2023

The treatment was well-tolerated with no significant changes in brain function

Senolytics have gender-specific effects on ageing in young mice

Lifespan.io (LEAF) - 30-Aug-2023

More research is needed to determine the safety and efficacy of senolytics in humans

AI identifies new senolytics that could treat age-related diseases

Lifespan.io (LEAF) - 09-Aug-2023

Three natural compounds identified, paving the way for new treatments

Experimental vaccine promises to slow down or prevent Alzheimer's in mice

American Heart Association - 30-Jul-2023

Vaccine not only reduced inflammation, but also improved behavior and awareness in mice

Tiny sea creature unlocks the secrets of healing and aging

Phys.org - 30-Jun-2023

Insights on the evolution of ageing and may help advance regenerative medicine

AI unveils economical pathway to discover new senolytics to combat age-related diseases

The University of Edinburgh - 14-Jun-2023

Artificial intelligence identifies herbal compounds to safely eliminate senescent cells

UNITY Biotech's lead compound lags behind the Regeneron’s eye drug

Biospace - 27-May-2023

UBX1325 showed disappointing results in phase II macular degeneration trial - further analysis is required

AI-driven breakthrough in senolytic drug discovery

Lifespan.io (LEAF) - 04-May-2023

Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases

Unity Biotechnology's diabetic macular edema senolytic treatment shows promise at 48-week endpoint

FierceBiotech - 24-Apr-2023

Corporate shift towards ophthalmology puts senolytics head-to-head against existing treatments

AKL Therapeutics’ investigational oral senotherapeutics drug APPA beneficial for osteoarthritis

Longevity Technology - 20-Mar-2023

Senescent cells have become one of the most promising targets for healthy aging research

Endurance Exercise Training May Help Prevent Accumulation of Senescent Cells in Colon Mucosa

Live Forever Club - 20-Mar-2023

Age-related increase in inflammatory markers p16 and IL-6 was not observed in endurance athletes

Rubedo's lead compound targets inflammatory skin disease with selective senolytic approach

Business Wire - 20-Mar-2023

Rubedo is planning first-in-human studies in multiple skin indications driven by chronic inflammation

SRF Scientists have discovered the "Iron Fist" strategy to deal with senescent cells

SENS Research Foundation - 09-Mar-2023

Scientists are working to bring these new rejuvenation biotechnologies of senolytics to aging humans

Reversal of cell senescence using low frequency ultrasound

Live Forever Club - 27-Jan-2023

Novel therapy killed some senescent cells, rejuvenated others, without harming healthy cells

Cellular Senescence Network (SenNet) to identify and characterize senescent cells

Nature Aging - 20-Dec-2022

Grand plan includes creation of imaging datasets, new tools, techniques, and biomarker panels

Targeting senescent cells could be a useful approach for slowing/treating Alzheimer’s disease

Salk Institute - 01-Dec-2022

How senescent neurons lead to Alzheimer’s disease, effect on removal and drugs needed for therapy

Novel experiment explores a new way of reducing senescent cell burden

Live Forever Club - 12-Nov-2022

BDNF-TrkB pathway shows a lot of promise in lowering senescent cells in older organs

Senolytics-a risky proposition in aging and repair mechanisms

Lifespan.io (LEAF) - 19-Oct-2022

The study is a caution for scientists engaging in self-experimentation with senolytics

$2.5M seed financing round closed by Cleara Biotech-targets cellular senescence

Longevity Technology - 03-Oct-2022

Cleara’s novel FOXO4-based treatment approach-ability to eliminate biomarker-positive scarred cells

Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate

Longevity Technology - 17-Aug-2022

Eliminating senescent cells rejuvenates the heart's capacity for regeneration in mice

Data from Phase 2 BEHOLD study of UBX1325 in DME patients-Unity Biotechnology

Ophthalmology Times - 12-Aug-2022

Statistically significant treatment effect for both BCVA and CST was seen at both 12 and 18 weeks

New insight on the accumulation of senescent cells in humans

UPMC - 30-Jun-2022

Oxidative DNA damage induce rapid senescence compared with shorter telomeres from repeated cell divisions

Exeter's company SENISCA raises £2 million to treat age-related chronic diseases

University of Exeter - 09-Jun-2022

Funding might allow RNA-based rejuvenation tech to enter ex vivo lab tests

Senolytics may abate accelerated aging of cancer patients as seen in mice

Lifespan.io (LEAF) - 06-Jun-2022

Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage

New algorithm recognises senescent cells using physical morphology

Lifespan.io (LEAF) - 26-May-2022

in vivo analysis in mice confirms the imaging results against p21 biomarker

Synergy of stem cell rejuvenation and senolytics promote longevity in fruit flies

Live Forever Club - 14-May-2022

Combined approach surprisingly eliminated the negative effects of individual treatments

Benjamin Le Calvé as the new Chief Scientific Officer of Starkage Therapeutics

StarkAge Therapeutics - 10-May-2022

Le Calvé will chair the Scientific Advisory Board and the Management Committee

Oral senolytics boosts geroprotective protein in mice and humans

Mayo Clinic - 15-Mar-2022

Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older people

SenoStem project to investigate whether prior delivery of senolytic improves stem cell treatment

SENS Research Foundation - 07-Feb-2022

Both are leading first generation longevity treatments - even better if they strengthen each other

A natural cholesterol metabolite with senolytic effect in mice and humans

Buck Institute - 02-Feb-2022

New class of senotherapeutic drugs that could possibly target various diseases and ageing

Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people

Lifespan.io (LEAF) - 27-Jan-2022

Senolytics showed positive effects on rats but trials must confirm these findings on human brain

StarkAge receives 2 million euros to design safer senescence-targeted therapies

Longevity Technology - 19-Jan-2022

Funding will ensure the development of a new immunotherapy for age-related diseases

Senolytics promotes wound healing in the aged but not in young mice

Lifespan.io (LEAF) - 22-Dec-2021

Dasatinib plus quercetin slow down muscle regeneration in young mice

Anti-aging treatment: New vaccine by Japanese research can make this happen

Japan Times - 16-Dec-2021

New research claims in removing zombie cells behind aging by vaccination

Procyanidin, a senotherapeutic compound from grape seed extends lifespan in mice

Lifespan.io (LEAF) - 14-Dec-2021

Improved survival via eliminating old cells - potential candidate to slowdown ageing

SENISCA targets sensescence using a new ageing hallmark - dysregulated mRNA processing

Lifespan.io (LEAF) - 03-Nov-2021

Lorna Harries believes dysregulated splicing as a breakthrough senotherapeutic target

University of Leicester proves feasibility of antibody based targeted senolytics

IFL Science - 28-Oct-2021

New study results show clinical applications in pathological ageing

Senolytic drugs improved survival rates in coronavirus-infected mice

SENS Research Foundation - 07-Oct-2021

Boosts immune response by clearing senescent cells; a potential treatment for COVID-19 in humans

Senolytic cocktail reduces age-related spinal disc degeneration in mice

Lifespan.io (LEAF) - 21-Sep-2021

Dasatinib and quercetin combo preserves spinal discs to target age-related back pain

A single protein reversed senescence in skeletal muscle cells

University at Buffalo - 17-Sep-2021

NANOG targets multiple ageing mechanisms - insights may help develop new therapies for age-related disorders

Hyperactivation of senescent cells can trigger cytokine storm

Lifespan.io (LEAF) - 13-Aug-2021

Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases

Longevity Technology interviews Aubrey de Grey about senolytics and other senotherapeutics

Longevity Technology - 05-Aug-2021

Most approaches have their limitations but good progress is being made on several fronts

Clearing out aged cells with senolytics can relieve jaw pain

University of Connecticut (UConn) - 07-Jul-2021

Senolytics for cartilage and bone regeneration in jaw joints, proven effective in mice

Pro-repair microenvironment after injury is favored by targeting senescent cells

News Medical - 06-Jul-2021

Senolytic drugs administration promotes locomotor and sensory recovery

Unity's senolytic drug reports positive phase 1 data in eye disease patients

FierceBiotech - 06-Jul-2021

Begun phase 2 trial including patients with early stage of disease to test its safety and effectiveness

A 12-week strength-endurance training lowered senescence proteins in older people

Lifespan.io (LEAF) - 14-Jun-2021

New study using biomarkers proved the importance of regular exercise again

Oisín raised $9.5M to advance senolytic therapies for kidney & age-related diseases

Longevity Technology - 28-May-2021

Investigational therapy on old mice cleared senescent cells up to 70%, extending life by 20%

Natural compound may help treat intervertebral disc degeneration

Lifespan.io (LEAF) - 12-May-2021

DHE slowed senescence in intervertebral discs of mice; but its use in anti-aging is still questionable

New immunotherapy clears out senescent cells to combat aging

Medical Xpress - 10-May-2021

Activated immune cells can treat age-related chronic diseases - a potential alternative to senolytics

Low magnitude vibration to prevent/delay age-related bone loss in rats

Lifespan.io (LEAF) - 05-May-2021

Vibration treatment eliminates senescence of bone cells - may not be applicable to other tissues

Raising awareness on senolytic drugs as a promising anti-ageing medicine

Longevity Technology - 30-Apr-2021

Senolytic Therapy Network aims to take the senotherapeutics from lab to clinic

SenNet: a new NIH initiative to fight ageing

Lifespan.io (LEAF) - 06-Apr-2021

Establishing a massive database on cellular senescence to improve human health

First ever non-invasive biomarker test to detect senolysis

Buck Institute - 02-Apr-2021

Detectible senescence-specific biomarker allows development of new drugs for age-related conditions

Life Extension supplement to clear out senescent cells

GlobeNewswire - 23-Mar-2021

New plant-based longevity pill that offers better access to many health benefits

Tackling multiple dysfunctions together can stop ageing signs

Lifespan.io (LEAF) - 12-Feb-2021

NAD+ levels, senescence and chronic inflammation collectively influence ageing

Oisín Biotechnologies' gene therapy may be available in the next 5 years

Longevity Technology - 22-Jan-2021

Results in mice suggest that it can increase median lifespan in humans by 15 years

Whole-body senescent cell removal improved brain health in mice

Lifespan.io (LEAF) - 22-Jan-2021

Senolytic drug and cancer drug with quercetin improved age-related cognition

Rubedo to first work on lung diseases

Longevity Technology - 20-Jan-2021

Their work will be critical amidst the COVID-19 pandemic - to move into clinical trials soon

Medical agent removes senescent cells to fix aging-related diseases

Japan Times - 16-Jan-2021

With positive results in mice, scientists expect to slow down ageing in humans

LMC provides background and success outlook on 14 leading senolytic companies

Longevity Marketcap - 15-Dec-2020

Comprehensive review of companies' clinical and financial state of play

Reversing heart damage with zombie cell-killing drug

British Heart Foundation (BHF) - 14-Dec-2020

Senescence killing drug in mice might unveil new heart attack treatments

A new enzyme discovered to reverse cellular ageing

Phys.org - 30-Nov-2020

Molecular simulations have discovered an enzyme with anti ageing and anti tumour effects

Targeting senescence might help fight cancers

Longevity Technology - 24-Nov-2020

Senolytics to treat cancers - study finds correlation between senescence & survival

Oxygen therapy reversed the human age biologically

YAHOO! - 18-Nov-2020

Not as easy as taking a pill, but a stunning result on both telomeres and senescent cells

Nature Biotechnology reviews the state of play of senolytics

Nature Biotechnology - 12-Nov-2020

Reason reviews the research behind One Skin's senotherapeutic skin-care spray

Fight Aging! - 06-Nov-2020

The anti-ageing peptide promotes skin health and reduces senescent cell markers

Say goodbye to fine lines and wrinkles with OneSkin

Longevity Technology - 21-Oct-2020

Topical supplement which extends skin span-the period of time your skin is healthy and youthful

Pharma company teams with AI to develop anti aging solutions

Longevity Technology - 15-Oct-2020

Taisho and Insilico collabs to identify novel targets for senolytic drugs

Unity Biotechnology launches clinical trial of a new senolytic

Lifespan.io (LEAF) - 13-Oct-2020

A new approach to treat diabetic macular oedema

Flavonoid found in redcurrants reduces senescence in brain cells

Lifespan.io (LEAF) - 28-Sep-2020

Mice study also saw improved cognitive abilities

Labiotech gathers feedback from European biotechs on Unity failure

Labiotech - 28-Aug-2020

General feeling that failures are bound to happen - but that their approaches can succeed

New research with senolytics shows promising results

Longevity Technology - 25-Aug-2020

Senolytic research is in its nascent stage but no reason why one shouldn't be hopeful

Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial

Fight Aging! - 18-Aug-2020

Disappointing first result - but lessons learnt and plenty of other strategies available

Exercise reduces inflammation caused by SASP but not the number of senescent cells

Fight Aging! - 31-Jul-2020

Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining

Taking the new path in the field of senolytics - SENISCA

Longevity Technology - 29-Jul-2020

Old cells will be more young and beautiful