In this episode of Optispan, Dr. Brad Younggren discusses a groundbreaking clinical study showing that Therapeutic Plasma Exchange (TPE) can reduce biological age markers by an average of 2.6 years in just 90 days. He explains how plasma exchange—a process that replaces a patient’s plasma with a clean solution—may rejuvenate cellular function and improve metabolic health, marking a potential milestone in longevity medicine.

Key Points:

Dr. Brad Younggren shares new evidence that plasma exchange can significantly reverse biological aging in a matter of weeks. By cleansing the bloodstream of age-promoting molecules, TPE could represent one of the first clinically proven rejuvenation therapies. The discussion highlights how precision medicine is moving from theory to measurable biological impact.

• What is TPE? – Therapeutic Plasma Exchange removes inflammatory molecules, damaged proteins, and other aging-related factors from the blood, replacing plasma with a fresh solution that restores biochemical balance.
• The Study Findings – In a 90-day clinical trial, participants undergoing TPE experienced a 2.6-year reduction in biological age, measured through advanced methylation-based aging clocks.
• Cellular Rejuvenation Effects – Dr. Younggren explains that TPE appears to reset inflammatory and metabolic pathways, improving mitochondrial function and tissue repair.
• Comparison with Other Longevity Interventions – Unlike supplements or short-term lifestyle changes, TPE directly alters the plasma environment, offering faster systemic effects on aging biomarkers.
• Safety and Practical Use – TPE is already an FDA-approved medical procedure used for autoimmune conditions, with strong safety data and minimal side effects when performed under medical supervision.
• Potential Mechanisms of Action – The therapy likely works by diluting “pro-aging” plasma factors, enhancing stem cell activity, and promoting the clearance of cellular waste.
• Next Steps in Research – Larger trials are now underway to confirm long-term benefits, explore optimal treatment frequency, and measure effects on cognition, immunity, and cardiovascular health.
• The Future of Preventive Medicine – Dr. Younggren envisions plasma exchange as part of a broader precision longevity toolkit combining diagnostics, AI risk analysis, and personalized therapies.