Senescent cells, which stop dividing but stay active, play a complex role in aging by protecting against cancer while also contributing to conditions like cardiovascular disease and diabetes. In this episode, Matt discusses with Natalia Mitin, co-founder and CEO of Sapere Bio, the measurement and clinical application of cellular senescence, its impact on aging and disease, and Natalia's experiences with off-label rapamycin use. Natalia, formerly an assistant professor at UNC Chapel Hill with over two decades in cancer research, holds a B.S. in Chemical Engineering and a Ph.D. in Biochemistry and Molecular Biology. Optispan uses the SapereX test for healthspan optimization.

Key Points:

This episode delves into measuring and applying insights from cellular senescence in clinical settings, exploring its complex role in ageing and disease with Natalia Mitin. The discussion also covers Natalia's experiences with off-label rapamycin use, the importance of monitoring biomarkers, and her views on "rapamycin for all."

• Ageing and Disease Risk: As we age, the immune system weakens, making us more vulnerable to diseases and treatments. Understanding individual biological age could allow more personalized healthcare.
• Personalized Medicine: Sapere Bio, led by Natalia Mitin, focuses on creating diagnostic tools that assess a person’s cellular senescence and immune function to tailor medical treatments more effectively.
• Cellular Senescence & Immune Health: The SapereX test developed by Sapere Bio measures the levels of cellular senescence (ageing cells that stop dividing) and immune system performance to give insights into biological ageing.
• Clinical Use of Senescence Markers: The test is designed to help physicians understand patient-specific ageing processes and guide interventions, such as lifestyle changes or medical treatments that can reduce senescent cells and improve immune function.
• Potential of Rapamycin: Rapamycin, a drug originally developed for other purposes, shows promise in rejuvenating immune function and reducing senescent cells, with implications for improving health and longevity.
• Future of Longevity Clinics: Sapere Bio is working with clinics to refine its diagnostic tools and collect real-world data, with plans to expand access to the SapereX test across many states to support personalized treatment strategies for ageing-related health issues​.