The R-Files is a series exploring rapamycin, a compound originally discovered in soil from Easter Island, known for its immunosuppressive and anti-aging effects. In the fourth episode, Matt highlights research showing how rapamycin revitalizes the ageing immune system in mice, enabling it to respond to a flu vaccine like a youthful immune system. He also reviews studies suggesting similar potential benefits for the human immune system.

Key Points:

The R-Files highlights rapamycin, a macrolide drug known for its immune-modulating and lifespan-extending potential, first discovered in Easter Island soil.  This episode focuses on studies indicating that rapamycin restores youthful immune responses in aged mice and may offer comparable benefits in human immunity.

• Rapamycin's Potential as an Immune Booster: While traditionally viewed as an immunosuppressant, new research suggests that rapamycin can rejuvenate aged immune systems, improving vaccine responses in elderly subjects.
• Key Studies in Mice: Research from 2009 demonstrated that rapamycin extended the lifespan of mice and restored immune stem cell function, helping older mice respond effectively to flu vaccines.
• Lifespan Extension: Short-term rapamycin treatment in aged mice more than doubled their remaining life expectancy, though the precise lifespan increase wasn't fully determined.
• Human Trials: Studies using everolimus, a rapamycin derivative, in older adults showed improved immune responses to flu vaccines, especially among those with weaker immune function.
• Implications for Viral Infections: Emerging data suggest rapamycin may provide protection against severe viral infections, including coronaviruses, by enhancing immune function in elderly populations.