The R-Files is a series on rapamycin, a drug originally discovered in Easter Island soil, known for its anti-ageing potential. In episode five, Matt shares his experience with off-label rapamycin use, which he started in January 2024. He reports improvements in joint pain and body fat loss, along with an unexpected bacterial infection, and speculates on rapamycin's role in these effects. He also notes that the drug's half-life in his blood is shorter than what's reported in the literature.

Key Points:

In the fifth episode of The R-Files, Matt discusses his experience with using rapamycin off-label, noting improvements in joint pain and body fat loss, while also discussing an unanticipated bacterial infection and rapamycin's shorter-than-expected half-life in his bloodstream.

• Rapamycin Use and Health Effects: Matt shares his ongoing experience with off-label use of rapamycin, noting improvements in joint pain and body fat loss, while also discussing a bacterial infection that may have been related.
• Bryan Johnson’s Rapamycin Data: The episode compares Matt's findings with those of Bryan Johnson, who also measures his rapamycin levels, highlighting differences in drug metabolism and half-life between the two.
• Weight Loss and Body Composition: Matt attributes part of his recent body fat reduction to rapamycin use, noting that his body fat decreased without significant loss of lean mass, supported by DEXA scan results.
• Rapamycin Clearance in Blood: Matt discovered that his body clears rapamycin much faster than what is reported in medical literature, raising questions about individual variability in rapamycin metabolism.
• Bacterial Infection Incident: Matt discusses the bacterial infection he experienced during his rapamycin cycle, linking it potentially to the immune-suppressing properties of the drug, alongside improper use of a continuous glucose monitor.