AJM publishes original clinical research, reviews, diagnostic imaging, case studies, and other types of articles. 

Since 2004, the Editor-in-Chief has been Joseph S. Alpert, MD, professor of medicine at The University of Arizona. Pamela J. Powers, MPH, is the managing editor, and Timothy S. Baird, MA, is the assistant editor/office manager. The American Journal of Medicine is published by Elsevier.