CAR Treg Therapy Shows Promise Against Atherosclerosis
Inside Precision Medicine - 21-Nov-2025Engineered Tregs targeting OxLDL sharply reduce inflammation and plaque buildup in mice
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Instructor in hematology–oncology at Perelman School of Medicine, University of Pennsylvania
Robert Schwab is an instructor in hematology–oncology at Perelman School of Medicine, University of Pennsylvania, where he combines clinical training with cutting-edge immunotherapy research. He earned his medical degree from the same institution and completed residency in internal medicine followed by a fellowship in hematology-oncology. Over the past several years, Schwab has helped extend the reach of cell-based therapies beyond cancer — most recently co-leading development of a novel CAR-T regulatory cell (CAR Treg) targeting oxidized LDL (OxLDL) to reduce artery-plaque formation in preclinical models of atherosclerosis. His work represents an effort to translate powerful immune-modulating technologies into treatments for common diseases like heart disease, potentially opening new therapeutic avenues beyond oncology.
Visit website: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8676045
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Engineered Tregs targeting OxLDL sharply reduce inflammation and plaque buildup in mice