PNAS Nexus is an open access scientific journal focused on the publication of high-quality original research from across the biological, medical, physical, social, and political sciences, and engineering and mathematics. Of particular interest are those articles with broad, interdisciplinary appeal.

A sibling journal to the Proceedings of the National Academy of Sciences (PNAS), the flagship journal of the National Academy of Sciences (NAS), PNAS Nexus provides comprehensive scientific coverage through the timely dissemination of original research from the fields of engineering and medicine, as well as studies in the social, political, and economic sciences, and the biological and physical sciences and mathematics more broadly. The Editorial Board of PNAS Nexus includes members of the NAS, the National Academy of Engineering, and the National Academy of Medicine, as well as select nonmembers who work in emerging fields not yet covered by academy membership.