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Michael Overholtzer

Cell biologist & PhD holder from Princeton university who studies about tumors and cell death

Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell populations, including entosis that supports the survival of starved cells and promotes cell competition, and ferroptosis that eliminates starved cell populations by propagating from cell to cell. The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis.

Visit website: https://www.mskcc.org/research/ski/labs/michael-overholtzer

See also: Health Organisation Memorial Sloan Kettering Cancer Center - Cancer treatment and research institution in New York City

Details last updated 17-Nov-2019

Articles written by Michael Overholtzer

Senescent cells show cellular cannibalism in mouse and human cancer cells

Nature - 28-Oct-2019

They're often called zombie cells - and turns out they are. Time to kill them with senolytics!

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