Manifold Bio is a biotech company specialising in engineering biologic medicines that can target specific tissues in the body by leveraging a pioneering in-vivo-first discovery engine called mDesign. The platform combines AI-guided protein design with massively multiplexed tracking technologies in living systems, enabling the firm to test thousands of candidate molecules simultaneously in real biological contexts rather than relying solely on in‐vitro assays. Manifold is building a modular portfolio of “shuttles” that can ferry therapeutic payloads—such as antibodies, siRNAs or antisense oligonucleotides—into traditionally hard-to-reach tissues like the brain, opening the door to treatments for neurological, neurodegenerative and other complex diseases.