Cardiff and Vale University Health Board (CAVUHB) is the local health board of NHS Wales for Cardiff and Vale of Glamorgan, in the south-east of Wales. Formed on 1 October 2009 through the amalgamation of three NHS organisations in the Cardiff and Vale of Glamorgan area. The three organisations amalgamated were: Cardiff and Vale NHS Trust, employing 12,000 staff and previously responsible for hospital services in the Cardiff and Vale of Glamorgan area; Cardiff Local Health Board; and Vale of Glamorgan Local Health Board both responsible for GP, Dental, Optical and pharmacy services. The headquarters of the Board is in the University Hospital of Wales, in Cardiff. Cardiff and Vale University Health Board is the operational name of Cardiff and Vale Local Health Board.

The Board supports a population of around 445,000 people living in Cardiff and the Vale of Glamorgan. It oversees seventeen health centres, public health, and community care services and also has a range of specialist services used by the whole of Wales, including renal, paediatric, neurology and bone marrow transplantation.

As of June 2020, Charles Janczewski is the chairman of the Board. Its current Interim Chief Executive is Prof Stuart Walker. The board is one of the first organisations in the UK to make wifi available in its hospitals, on the basis that enables patients to stay in touch with their family and friends, and improves the way it interacts with patients.