Dr. Van Skike specializes in the use of in vivo techniques, including intravital two-photon microscopy and laser Doppler flowmetry, to measure cerebral blood flow, vasodilatory capacity, and blood-brain barrier integrity in mouse models of AD. Additionally, her research utilizes immunofluorescent confocal microscopy and cell culture to identify the mTOR-dependent mechanisms involved in cerebral blood flow dysfunction. She is also highly trained in rodent behavioral testing, including spatial learning and memory tasks, hippocampal dependent contextual memory, recognition memory, anxiety, and assays of motor function.