The Alzheimer’s Pathobiome Initiative (AlzPI) is a global, interdisciplinary effort focused on understanding the role of microbes in Alzheimer's disease and other dementias. By examining microbial infections in various brain and bodily tissues, AlzPI aims to develop standardized methods for detecting these infections and explore their potential link to neurodegeneration. The initiative seeks to advance patient-centered research, ultimately improving diagnostic and treatment strategies for Alzheimer's and related conditions.