Pretzel was founded by some of the world’s foremost researchers in mitochondrial biology and is led by accomplished experts in drug discovery, drug development, and company foundation. Our deep expertise in mitochondrial biology enables us to potentially address a wider range of diseases driven by mitochondrial dysfunction than ever before.

The name Pretzel is inspired by the focal point of our science, the mitochondrion, whose twisting inner-membrane is one of many fascinating features that make it unlike any other organelle in the body.

At Pretzel, we are developing first-in-class therapeutics that can address mitochondrial dysfunction at its roots. By taking aim at the genetic drivers of mitochondrial dysfunction, we believe our approach could be effective across a wide range of diseases which lack meaningful treatment options today.