At the Longevity Summit Dublin 2024, Patrizia d’Alessio presented her research on the potent anti-senescence effects of d-Limonene, a natural compound found in citrus peels. Her work emphasizes its role in reducing inflammation, repairing gut health, and promoting skin rejuvenation. Clinical studies show that d-Limonene can improve a wide range of age-related conditions, offering a non-toxic alternative for enhancing healthspan.

Key Points:

• Discovery of d-Limonene: Patrizia d'Alessio shared the story of discovering d-Limonene’s anti-inflammatory properties through bioguided research. This small molecule, found in citrus peels, reverses inflammatory markers of cellular senescence, a key process in ageing.
• Non-Toxic Anti-Inflammatory Effects: d-Limonene, a natural compound, has been shown to reduce pro-inflammatory cytokines such as IL-6 and TNF-alpha. This provides a safer alternative to conventional biologic treatments, with wide-reaching effects across multiple organs.
• Clinical Impact: In clinical studies, d-Limonene significantly reduced biomarkers related to cardiometabolic syndrome, such as fibrinogen and insulin levels. This highlights its potential role in managing age-related conditions like diabetes and thrombosis.
• Gut Health and Neuroinflammation: d-Limonene was found to repair leaky gut syndrome and inhibit inflammation in the gut. This has downstream effects on neuroinflammation, potentially improving mood disorders and cognitive health, as shown in preclinical and clinical studies.
• Application in Skin Rejuvenation: d-Limonene demonstrated powerful effects in skin health, showing rapid improvement in conditions like atopic dermatitis and psoriasis. This was accompanied by visible skin rejuvenation in clinical trials.
• Psychological Benefits: Research revealed that d-Limonene increased dopamine levels in the brain, restoring motivation and reducing stress-related behavior in animal models. These effects translate to human studies where mood disorders improved with d-Limonene treatment.