The R-Files explores rapamycin, a compound from Easter Island with potential anti-ageing effects. In the second episode, Matt, a long-time rapamycin researcher, shares how he used it off-label to treat persistent shoulder pain linked to age-related inflammation.

Key Points:

In episode two of R-Files, Matt, a rapamycin expert, In this podcast, Matt shares how a personal battle with frozen shoulder led him to try rapamycin off-label.

• Matt's Introduction to Rapamycin: Matt explains his initial dismissal of off-label rapamycin use despite studying the drug for years, until a personal health issue—frozen shoulder—prompted him to explore it further​.
• Dealing with Frozen Shoulder: After being diagnosed with adhesive capsulitis, or frozen shoulder, and receiving little treatment guidance, Matt decided to try rapamycin to address the age-related inflammation causing his pain​.
• Rapamycin Experiment: Matt conducted a 10-week personal trial using 6 mg of rapamycin weekly. By the end, his pain had significantly decreased, and his range of motion improved by 95%​.
• Rapamycin Cycling and Benefits: Since his initial success, Matt has continued cycling rapamycin for pain relief in his joints, supporting its potential anti-inflammatory benefits​.