Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides translational and/or fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity; tumor immunology, and microbial immunopathology.

Nature Immunology places its highest priority on fair and rapid review and speedy publication. Decisions on whether to send a manuscript out for peer review are normally made within two working days of receipt and decisions about publication are typically made within two days of receipt of the referees' reports.