In this episode of LongeCity interview, Steve Perry of GDF11 Rejuvenation, a prominent biohacker, shares his ongoing experiments with GDF11 and the biological rejuvenation effects he’s observed over nearly a decade of use.

Key Points:

Steve Perry’s work with GDF11 has shown promising improvements in cognitive function and heart health. However, as he points out, ageing is complex and will likely require a combination of therapies for complete rejuvenation.

• GDF11’s Cognitive Benefits: Steve Perry, a long-time biohacker, shared his personal experience with GDF11, an endogenous protein. He reported improved cognitive function, including reaction times, which he claims has decreased by 12%, a critical biomarker of brain health and potential prevention of Alzheimer's.
• Heart Health Improvements: Perry and his cohort have seen a 22% increase in heart rate variability (HRV), a key marker for cardiovascular health. These improvements were achieved even in participants who were not physically active.
• Skepticism About DNA Methylation Tests: Perry expressed doubts about the reliability of DNA methylation age tests, citing inconsistent results. He prefers functional biomarkers like HRV and reaction time, which provide more tangible, day-to-day insights into ageing.
• GDF11 and Cancer Treatment in Animals: Perry discussed anecdotal evidence of GDF11 reducing or eliminating cancers in dogs and cats, including terminal cases of hemangiosarcoma. Some human cases have also shown improvements, particularly in liver and stomach cancer.
• Clotho as an Adjunct Therapy: Perry has incorporated Clotho injections, a protein known to support cardiovascular and cognitive health, alongside GDF11. He reported further improvements in blood sugar regulation and overall health.
• Limitations of GDF11: While GDF11 has shown promising results in biomarkers such as cognitive function and heart health, Perry acknowledges that it cannot address all aspects of ageing. He notes that ageing is multifaceted, and other therapies may be necessary for more comprehensive rejuvenation.