In this episode of the LongeCity interviews, Dr. William Andrews, founder of Sierra Sciences, shares insights into telomere biology, the challenges of funding longevity research, and the future of anti-ageing therapies. With decades of experience as a scientist and inventor, Andrews discusses the science of ageing and strategies for extending the human lifespan.

Key Points:

Dr. William Andrews is committed to overcoming the 125-year lifespan barrier through telomere research and innovative anti-ageing therapies. While challenges persist, his work highlights the potential of science to unlock longer and healthier lives.

• The Science of Telomeres: Telomeres, the protective caps at the ends of chromosomes, shorten with cell division and are a major limiting factor in human lifespan, theoretically capped at 125 years.
• Challenges in Research and Funding: Andrews highlights how short-term investment goals often derail long-term anti-ageing research, emphasizing the need for patient investors committed to transformative breakthroughs.
• Telomerase Inducers and Current Products: Sierra Sciences has developed telomerase inducers, including one licensed for skincare, but Andrews aims to create more potent compounds capable of reversing ageing.
• The Role of Biomarkers: While telomere length is a key biomarker, Andrews discusses the potential of DNA methylation and IgG glycosylation as promising tools to measure and track ageing processes.
• Gene Therapy and Beyond: Andrews praises the advancements in gene therapy by companies like BioViva, which are proving concepts in mice, but stresses the need for more affordable and scalable solutions for humans.
• Practical Steps for Longevity: Alongside his research, Andrews advocates for antioxidants, anti-inflammatories, and healthy lifestyles, emphasizing the importance of supplements like those recommended by Dr. Sandra Kaufman.