Dr. Matthew Hurles is a senior scientist and Director of the Wellcome Sanger Institute, renowned for his pioneering contributions to human genetics and genomics. He played a central role in the original Human Genome Project and has since led the discovery of genetic mutations underlying a range of developmental disorders. His research team specializes in the use of large-scale sequencing and computational genomics to reveal how structural variants and de novo mutations contribute to conditions such as autism, intellectual disability, and congenital anomalies. Under his leadership, the Sanger Institute has advanced efforts in rare disease diagnosis and the ethical application of genome editing, firmly establishing itself as a global authority in genomic medicine.