The Lewis-Sigler Institute at Princeton University was established with a mandate to create innovative research and teaching programs at the interface of modern biology and the more quantitative sciences. One impetus came from the need to deal with the explosion of information based on the genomic sequences of the human and all major experimental organisms. The other major impetus came from the realization that the most interesting and difficult problems in the quantitative disciplines, especially physics, chemistry and computer science, frequently lie in biological phenomena and applications. The Institute, housed in the Viñoly-designed Carl Icahn Laboratory, has a diverse, interdisciplinary intellectual environment. Resident faculty are also members of the following departments: Chemistry, Chemical and Biological Engineering, Computer Science, Ecology and Evolutionary Biology, Molecular Biology, and Physics. One of the goals of the Lewis-Sigler Institute is to serve as a hub for Princeton-wide interdisciplinary research programs and to provide cutting edge research infrastructure for them. Current research includes experimental and computational development of genome-scale technologies, mathematical and physical modeling, and innovative molecular imaging.