Journal of Medicinal Chemistry (J. Med. Chem.) is a biweekly, peer-reviewed scientific journal published by American Chemical Society that has, since 1959, served as a leading forum for research at the interface of chemistry and biology. It focuses on studies that shed light on how the molecular structure of compounds relates to their biological activity or mechanism of action — for instance, the design, synthesis and biological evaluation of novel active compounds; structure-activity relationship investigations (SAR); structural biology or computational studies to understand molecular recognition; pharmacokinetics and metabolic behavior; and even use of emerging tools like AI in drug discovery.